Welcome to the Biology of Aging Investigation lab!We are interested in understanding: How animals age? Our main research goal is to decipher the contributing factors (e.g. hormones) that regulate tissue aging.
One of the cellular protective mechanisms that we are interested in studying is called "autophagy". This process is known to be altered during aging. We aim to dissect the molecular basis for age-dependent dysregulation of autophagy and its contribution to tissue homeostasis during animal aging. By elucidating the cellular and molecular mechanisms of aging and uncovering the secret of Fountain of Youth, we hope that we can find ways to prevent age-associated diseases and prolong the healthspan of global aging population. “However, the best anti-aging practice might be surprisingly simple: Eat less, Exercise, Be happy.”
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Lab News
06/03/2019
Our recent work demonstrates that peroxisome dysfunction is a novel cause of aging (not just the consequence of aging). We also show that defective peroxisomal import in aged liver signals to the heart via the pro-inflammatory cytokine Upd3/IL-6 to accelerate cardiac aging. See our preprint for more details. https://doi.org/10.1101/659128.
05/01/2019
Dr. Bai received 2019 GDCB Early Achievement in Research Award.
04/23/2019
Allison passed her preliminary exam. Congratulations!
04/17/2019
Rachel Mehmert presented her autophagy work at 2019 ISU Symposium on Undergraduate Research and Creative Expressions.
03/31/2019
Our undergraduate Rachel Mehmert received 2019 Dean's High Impact Award for Undergraduate Research. Congratulations!!
03/27-03/31/2019
Kerui and Ting attended and presented at the 60th Annual Drosophila Research Conference at Dallas, TX.
03/21/2019
Allison’s paper on FOXO ChIP-Seq has been recently accepted by Frontiers in Genetics, Genetics of Aging. Congratulations!!
03/12/2019
Our review article on organelle aging is now accepted by Journal of Genetics and Genomics. This is our first attempt to summarize what we know about the structural and functional changes in five well-studied organelles during normal aging. Thank you for the hard work from Mark, Kerui and Ping.
03/11/2019
Dr. Jinoh Kim joins the lab as a postdoctoral research associate. Welcome!
01/13/2019
Kai presented her work on mTORC2 at Keystone Symposia: Mitochondria in Aging and Age-Related Disease.
1/11/2019
We were awarded our first R01 grant from National Institute on Aging (NIA). The award will allow us to study the molecular mechanisms underlying cardiac aging, as well as autophagy regulation.
12/12/2018
Our oenocyte translatome (RiboTag) paper is accepted by BMC Genomics. Thank you Kerui and our collaborators for the great work!
12/06/2018
Kerui passed her preliminary exam. Congratulations!
11/28/2018
Kai passed her preliminary exam. Congratulations!
11/08/2018
Kai received a two-year AHA predoctoral fellowship. Congratulations!!
10/04/2018
Dr. Bai presented our work on activin/mTOR2 and cardiac aging at 2018 Cold Spring Harbor conference-Mechanisms of Aging.
8/24/2018
Undergraduate student Seth Millikan joins the lab. Welcome!
7/2/2018
Ting Miao officially joins the lab as a PhD graduate student. Welcome!
4/11-4/15/2018
Dr. Bai, Kerui, Allison and Mark presented at the 59th Drosophila Research Conference, Philadelphia PA.
4/6/2018
Axelle successfully defended her Master thesis, entitled "The Power of GWAS: Leveraging Genome Wide Association Studies to identify Novel Regulators of Autophagy in Drosophila melanogaster", Congratulations!
03/30/2018
Our coming undergraduate Zhitao Ming won Sui Tong Chan Fung Summer Internship in Genetics. Congratulations!
1/8/2018
Three undergraduate students join the lab. They are Emma Troyer, Rachel Mehmert, Immaculate Edwin. Welcome!
11/15/2017
Our Kr-h1 paper is accepted by Scientific Reports!!!
10/30/2017
Jacob Zobrist joins the lab for his second rotation. Welcome!
09/11/2017
Kaiser Arndt joins the lab as an undergraduate research assistant. Welcome!
08/28/2017
Ting Miao joins the lab as a rotation student. Welcome!
06/05/2017-06/07/2017
Dr. Bai attended AFAR grantee conference and presented a poster on muscle aging research.
05/01/2017
Mark Bouska joins the lab after his rotations. Welcome!
04/21/2017-04/22/2017
Dr. Liu, Allison and Axelle attended and presented at 129th Iowa Academy of Science (IAS) Annual Meeting.
04/11/2017
Graduate student Kerui Huang receives the 2017 Glenn/AFAR Scholarship for Research on the Biology of Aging. Congratulations!!!
02/03/2017
Graduate student Kerui Huang is awarded a scholarship from the Graduate College. This scholarship was made possible by generous donations made to the Iowa State University Foundation. Congratulations!
01/17/2017
Undergraduate student Qiuhan Jiang joins the lab. Welcome!
11/28/2016
In the News
Prolonging our 'healthspan'
09/26/2016
Dr. Bai attended CSHL aging conference and presented a poster on our cardiac aging research.
08/22/2016
Mark Bouska joins the lab as a rotation student. Welcome!
08/15/2016
Kerui Huang and Axelle Weeger officially join the lab as graduate students. Welcome!
07/13/2016~07/17/2016
Bai Lab went to 2016 The Allied Genetics Conference in Orlando, Florida. Kai, Allison and Ping presented posters at the conference.
07/01/2016
We received 2016 AFAR Research Grant for Junior Faculty. Congratulations!
07/01/2016
Dr. Ying Liu, our new postdoc researcher, joins the lab. Welcome!
06/20/2016
Fahmo Mohamed, our 2016 George Washington Carver summer research intern, joins the lab. Welcome!
06/06/2016
Jazmine Real, our 2016 HHMI summer research intern, joins the lab. Welcome!
04/05/2016
Our undergraduate Sheridan Schwartz won Sui Tong Chan Fung Internship in Genetics. Congratulations!
03/07/2016
Allison Birnbaum joins the lab as a rotation student. Welcome!
02/29/2016
We have our first demography (lifespan analysis) set up. Thank you Ping and all of the undergraduate students for your hard work!
02/29/2016
Interview with Iowa State Daily.
http://www.iowastatedaily.com/news/article_7b47c28c-dc0c-11e5-9aa3-cb70b5e13241.html
02/24/2016
Kai Chang joins the lab as a Laboratory Technician. she will join our IG2 graduate program in Fall 2016 with a F. Wendell Miller Fellowship. Congratulations!
02/16/2016
Our NIH-NIA R00 award finally came $$ (Project entitled, “Activin-Mediated Autophagy During Cardiac Aging")
02/10/2016
On GDCB departmental news.
https://www.las.iastate.edu/new-gdcb-faculty-member-hua-bai-studies-how-animals-age/
01/11/2016
Undergraduate students Audrey, Emily, Sheridan, Matt and Larsa join the lab. Welcome!
01/04/2016
The Bai Lab is officially established! We are located at 3238 Molecular Biology Building ( 'We' means myself and Assistant Scientist Ping).
Our recent work demonstrates that peroxisome dysfunction is a novel cause of aging (not just the consequence of aging). We also show that defective peroxisomal import in aged liver signals to the heart via the pro-inflammatory cytokine Upd3/IL-6 to accelerate cardiac aging. See our preprint for more details. https://doi.org/10.1101/659128.
05/01/2019
Dr. Bai received 2019 GDCB Early Achievement in Research Award.
04/23/2019
Allison passed her preliminary exam. Congratulations!
04/17/2019
Rachel Mehmert presented her autophagy work at 2019 ISU Symposium on Undergraduate Research and Creative Expressions.
03/31/2019
Our undergraduate Rachel Mehmert received 2019 Dean's High Impact Award for Undergraduate Research. Congratulations!!
03/27-03/31/2019
Kerui and Ting attended and presented at the 60th Annual Drosophila Research Conference at Dallas, TX.
03/21/2019
Allison’s paper on FOXO ChIP-Seq has been recently accepted by Frontiers in Genetics, Genetics of Aging. Congratulations!!
03/12/2019
Our review article on organelle aging is now accepted by Journal of Genetics and Genomics. This is our first attempt to summarize what we know about the structural and functional changes in five well-studied organelles during normal aging. Thank you for the hard work from Mark, Kerui and Ping.
03/11/2019
Dr. Jinoh Kim joins the lab as a postdoctoral research associate. Welcome!
01/13/2019
Kai presented her work on mTORC2 at Keystone Symposia: Mitochondria in Aging and Age-Related Disease.
1/11/2019
We were awarded our first R01 grant from National Institute on Aging (NIA). The award will allow us to study the molecular mechanisms underlying cardiac aging, as well as autophagy regulation.
12/12/2018
Our oenocyte translatome (RiboTag) paper is accepted by BMC Genomics. Thank you Kerui and our collaborators for the great work!
12/06/2018
Kerui passed her preliminary exam. Congratulations!
11/28/2018
Kai passed her preliminary exam. Congratulations!
11/08/2018
Kai received a two-year AHA predoctoral fellowship. Congratulations!!
10/04/2018
Dr. Bai presented our work on activin/mTOR2 and cardiac aging at 2018 Cold Spring Harbor conference-Mechanisms of Aging.
8/24/2018
Undergraduate student Seth Millikan joins the lab. Welcome!
7/2/2018
Ting Miao officially joins the lab as a PhD graduate student. Welcome!
4/11-4/15/2018
Dr. Bai, Kerui, Allison and Mark presented at the 59th Drosophila Research Conference, Philadelphia PA.
4/6/2018
Axelle successfully defended her Master thesis, entitled "The Power of GWAS: Leveraging Genome Wide Association Studies to identify Novel Regulators of Autophagy in Drosophila melanogaster", Congratulations!
03/30/2018
Our coming undergraduate Zhitao Ming won Sui Tong Chan Fung Summer Internship in Genetics. Congratulations!
1/8/2018
Three undergraduate students join the lab. They are Emma Troyer, Rachel Mehmert, Immaculate Edwin. Welcome!
11/15/2017
Our Kr-h1 paper is accepted by Scientific Reports!!!
10/30/2017
Jacob Zobrist joins the lab for his second rotation. Welcome!
09/11/2017
Kaiser Arndt joins the lab as an undergraduate research assistant. Welcome!
08/28/2017
Ting Miao joins the lab as a rotation student. Welcome!
06/05/2017-06/07/2017
Dr. Bai attended AFAR grantee conference and presented a poster on muscle aging research.
05/01/2017
Mark Bouska joins the lab after his rotations. Welcome!
04/21/2017-04/22/2017
Dr. Liu, Allison and Axelle attended and presented at 129th Iowa Academy of Science (IAS) Annual Meeting.
04/11/2017
Graduate student Kerui Huang receives the 2017 Glenn/AFAR Scholarship for Research on the Biology of Aging. Congratulations!!!
02/03/2017
Graduate student Kerui Huang is awarded a scholarship from the Graduate College. This scholarship was made possible by generous donations made to the Iowa State University Foundation. Congratulations!
01/17/2017
Undergraduate student Qiuhan Jiang joins the lab. Welcome!
11/28/2016
In the News
Prolonging our 'healthspan'
09/26/2016
Dr. Bai attended CSHL aging conference and presented a poster on our cardiac aging research.
08/22/2016
Mark Bouska joins the lab as a rotation student. Welcome!
08/15/2016
Kerui Huang and Axelle Weeger officially join the lab as graduate students. Welcome!
07/13/2016~07/17/2016
Bai Lab went to 2016 The Allied Genetics Conference in Orlando, Florida. Kai, Allison and Ping presented posters at the conference.
07/01/2016
We received 2016 AFAR Research Grant for Junior Faculty. Congratulations!
07/01/2016
Dr. Ying Liu, our new postdoc researcher, joins the lab. Welcome!
06/20/2016
Fahmo Mohamed, our 2016 George Washington Carver summer research intern, joins the lab. Welcome!
06/06/2016
Jazmine Real, our 2016 HHMI summer research intern, joins the lab. Welcome!
04/05/2016
Our undergraduate Sheridan Schwartz won Sui Tong Chan Fung Internship in Genetics. Congratulations!
03/07/2016
Allison Birnbaum joins the lab as a rotation student. Welcome!
02/29/2016
We have our first demography (lifespan analysis) set up. Thank you Ping and all of the undergraduate students for your hard work!
02/29/2016
Interview with Iowa State Daily.
http://www.iowastatedaily.com/news/article_7b47c28c-dc0c-11e5-9aa3-cb70b5e13241.html
02/24/2016
Kai Chang joins the lab as a Laboratory Technician. she will join our IG2 graduate program in Fall 2016 with a F. Wendell Miller Fellowship. Congratulations!
02/16/2016
Our NIH-NIA R00 award finally came $$ (Project entitled, “Activin-Mediated Autophagy During Cardiac Aging")
02/10/2016
On GDCB departmental news.
https://www.las.iastate.edu/new-gdcb-faculty-member-hua-bai-studies-how-animals-age/
01/11/2016
Undergraduate students Audrey, Emily, Sheridan, Matt and Larsa join the lab. Welcome!
01/04/2016
The Bai Lab is officially established! We are located at 3238 Molecular Biology Building ( 'We' means myself and Assistant Scientist Ping).