Welcome to the Biology of Aging Investigation lab!
We are interested in understanding: How animals age? Our main research goal is to decipher the contributing factors (e.g. hormones) that regulate tissue aging.
One of the cellular protective mechanisms that we are interested in studying is called "autophagy". This process is known to be altered during aging. We aim to dissect the molecular basis for age-dependent dysregulation of autophagy and its contribution to tissue homeostasis during animal aging. In addition, we have began to investigate the mitochondrial and peroxisomal stress pathways and their role in ROS homeostasis.
By elucidating the cellular and molecular mechanisms of aging and uncovering the secret of Fountain of Youth, we hope that we can find ways to prevent age-associated diseases and prolong the healthspan of global aging population.
“However, the best anti-aging practice might be surprisingly simple: Eat less, Exercise, Be happy.”
Mark received 2021 Spring Teaching Excellence Award. Congratulations!!
Dr. Bai received 2021 LAS College Award for Early Achievement in Research!!
Ankur Kumar offically joins the lab. Welcome!
We orgainzed a mini symposium on "Peroxisome, Metabolism, and Homeostasis". Thank you for the great help from @AgingSciTalks, as well as four excellent speakers Irfan Lodhi, Andrew Simmonds, Margret Bülow, and Francesca Di Cara.
Mark’s non-coding RNA and spermatogenesis story has been published in G3 Genes|Genomes|Genetics. Congratulations!!
New rotation student, Ankur Kumar, joins the lab. Welcome!
New rotation student, Jacinta Correia, joins the lab. Welcome!
Pham's abstract was selected for a platform (oral) presentation at the 62nd Annual Drosophila Research Conference. Congratulations!!
Good news!! Our NSF CAREER award is funded!! This newly funded award will allow to investigate how eukaryotic cells sense and respond to malfunctioned peroxisomes. We hope our research will lead to the discover of novel "peroxisomal stress response" pathways.
New rotation student, Thomas Burns, joins the lab. Welcome!
New publication from former graduate student Allison Birnbaum! The study uncovered an important role of FOXO in aging neuromuscular junction (NMJ) in Drosophila. Congratulations!!
James Yegerlehne joins the lab as a undergraduate research assistant. Welcome Jim!
Pham Vo joins us again as a research technician. Welcome back!
Kerui Huang successfully defended her thesis today (virtually). Congratulations!!
Kai Chang successfully defended her thesis today (virtually). Congratulations!!
Dr. Bai presented our peroxisome work at 2020 Midwest Drosophila Conference (Virtual).
New review article on liver-heart communication published today!
Dr. Bai presented our newest CRISPR screening work at GDCB department seminar (Virtual).
Dr. Bai presented at 2020 Cold Spring Harbor Laboratory Conference- Mechanisms of Aging (Virtual).
Vishesh Bhatia joins the lab as a rotation student. Welcome!
Maggie Sodders joins the lab as a Master graduate student. Welcome!
Graduate student Ting Miao received the 2020 Kalman/AFAR Scholarships for Research in the Biology of Aging. Congratulations!!!
Our undergraduate trainee Dongyeol received a Dean’s High Impact Award for Undergraduate Research. Congratulations!!
Allison's last day working with us. She will start her postdoc at University of Alabama Birmingham in July. We wish her best of luck with her new position and a successful career!!
The news release on our peroxisome paper is also online now at ISU News!! Thanks to Fred Love at ISU News Service for the nice article.
Our peroxisome aging and liver-heart communication paper is finally online today at Nature Communications!！ Thanks for the excellent work from my graduate student Kerui Huang, and our wonderful collaborators Francesca Di Cara and Andrew Simmonds.
Dr. Bai presented our peroxisome aging work at Aging Science Talks (Virtual). It was a fun experience and lots of audience from all over the world.
Kerui received 2020 Spring Research Assistantship Award (REX) today. Congratulations!!
The first PhD student from the lab, Allison Birnbaum, successfully defended her thesis today (remotely/virtually). Congratulations!!
Our peroxisome aging and liver-heart communication paper finally gets accepted by Nature Communications today!! It was a great honor and pleasure to working with Di cara Lab and Simmonds Lab.
We have a preprint posted in bioRxiv about the role of FOXO in the regulation of NMJ morphology and late endosome during fly aging.
Dr. Bai attended and presented at 2020 Keystone Symposium on Aging at Vancouver, Canada.
Congratulations to our undergraduate student Rachel Mehmert, who was recently selected to present her research at 2020 National Council on Undergraduate Research (NCUR) at Montana State University. Her abstract was chosen from more than 4,000 submissions!!
Undergraduate student Dongyeol Lee joins the lab. Welcome!
Thanks Ames Tribune for highlighting our cardiac aging work!! Katie Mauch at Ames Tribune wrote a great article for us. Thank you Katie.
Nice news release on our Autophagy paper is online now at ISU News!! Thanks to Fred Love at ISU News Service for the nice article.
Our Autophagy paper is online Now!! Congratulations to Kai and Ping!! Also thanks for the great help from our collaborators: Ioannis P. Nezis, Rolf Bodmer, and Karen Ocorr. In this study, we identified activin-mediated inhibition of mTORC2 as a novel mechanism for age-dependent decline of autophagy and cardiac health in Drosophila.
Kerui received a one-year AHA predoctoral fellowship. Congratulations!!
Rotation student Mahsa Askary Hemmat joins the lab. Welcome!
Mark passed his preliminary exam today. Congratulations!
The lab attended the fist Midwest Aging Consortium (MAC) Symposium at McNamara Alumni Center of the University of Minnesota. Dr. Bai talked about our peroxisome and cardiac aging work. Kai won the poster prize again. Congrats!!
The Bai Lab and McNeill lab had a road trip together to 2019 Midwest Drosophila Conference. All students did great jobs in presenting their work. Ting was selected to give an oral presentation. Kai's poster presentation won second prize.
Rotation student Sean McLaughlin joins the lab. Welcome!
Dr. Bai presented at the first GDCB Research Day.
Dr. Bai was invited to speak at the department seminar of the Department of Physiology at the University of Oklahoma Health Sciences Center.
Dr. Bai was invited to speak at the seminar series of the Department of Physiology at Wayne State University, School of Medicine.
Undergraduate student Jamie Cook joins the lab. Welcome!
Two rotation students, Peiduo Liu and McKenzie Wishman, join the lab. Welcome!
Undergraduate student Guillermo Requejo joins the lab. Welcome!
Olympus FV3000 is installing this week....!!!
Qiuhan is leaving the lab to join the BCB graduate program at ISU. We are grateful for her contributions to the lab. We wish her all the best in her future endeavors.
Dr. Bai attended and presented at 2019 Biology of Aging Conference at Newry, ME.
Dr. Bai and Ping attended and presented at 2019 Insect Hormones Workshop at Kolymbari, Crete.
Our recent work demonstrates that peroxisome dysfunction is a novel cause of aging (not just the consequence of aging). We also show that defective peroxisomal import in aged liver signals to the heart via the pro-inflammatory cytokine Upd3/IL-6 to accelerate cardiac aging. See our preprint for more details. https://doi.org/10.1101/659128.
Dr. Bai participated the 1st Midwest Aging Consortium meeting.
Dr. Bai received 2019 GDCB Early Achievement in Research Award.
Allison passed her preliminary exam. Congratulations!
Rachel Mehmert presented her autophagy work at 2019 ISU Symposium on Undergraduate Research and Creative Expressions.
Kerui and Ting represented the lab t speak at 2nd ISU Symposium for Cellular Organelles.
Our undergraduate Rachel Mehmert received 2019 Dean's High Impact Award for Undergraduate Research. Congratulations!!
Kerui and Ting attended and presented at the 60th Annual Drosophila Research Conference at Dallas, TX. Kerui was selected to give an oral presentation.
Allison’s paper on FOXO ChIP-Seq has been recently accepted by Frontiers in Genetics, Genetics of Aging. Congratulations!!
And thanks for the help of our collaborators: Xiaofen Wu, Nan Liu, and Marc Tatar.
Our review article on organelle aging is now accepted by Journal of Genetics and Genomics. This is our first attempt to summarize what we know about the structural and functional changes in five well-studied organelles during normal aging. Thank you for the hard work from Mark, Kerui and Ping.
Dr. Jinoh Kim joins the lab as a postdoctoral research associate. Welcome!
Kai presented her work on mTORC2 at Keystone Symposia: Mitochondria in Aging and Age-Related Disease.
We were awarded our first R01 grant from National Institute on Aging (NIA). The award will allow us to study the molecular mechanisms underlying cardiac aging, as well as autophagy regulation.
Our oenocyte translatome (RiboTag) paper is accepted by BMC Genomics. Thank you Kerui and our collaborators for the great work!
Kerui passed her preliminary exam. Congratulations!
Kai passed her preliminary exam. Congratulations!
Kai received a two-year AHA predoctoral fellowship. Congratulations!!
Dr. Bai presented our work on activin/mTOR2 and cardiac aging at 2018 Cold Spring Harbor conference-Mechanisms of Aging.
Undergraduate student Seth Millikan joins the lab. Welcome!
Ting Miao officially joins the lab as a PhD graduate student. Welcome!
Dr. Bai, Kerui, Allison and Mark presented at the 59th Drosophila Research Conference, Philadelphia PA.
Axelle successfully defended her Master thesis, entitled "The Power of GWAS: Leveraging Genome Wide Association Studies to identify Novel Regulators of Autophagy in Drosophila melanogaster", Congratulations!
Our coming undergraduate Zhitao Ming won Sui Tong Chan Fung Summer Internship in Genetics. Congratulations!
Three undergraduate students join the lab. They are Emma Troyer, Rachel Mehmert, Immaculate Edwin. Welcome!
Our Kr-h1 paper is accepted by Scientific Reports!!!
Jacob Zobrist joins the lab for his second rotation. Welcome!
Kaiser Arndt joins the lab as an undergraduate research assistant. Welcome!
Ting Miao joins the lab as a rotation student. Welcome!
Dr. Bai attended AFAR grantee conference and presented a poster on muscle aging research.
Mark Bouska joins the lab after his rotations. Welcome!
Dr. Liu, Allison and Axelle attended and presented at 129th Iowa Academy of Science (IAS) Annual Meeting.
Graduate student Kerui Huang receives the 2017 Glenn/AFAR Scholarship for Research on the Biology of Aging. Congratulations!!!
Graduate student Kerui Huang is awarded a scholarship from the Graduate College. This scholarship was made possible by generous donations made to the Iowa State University Foundation. Congratulations!
Undergraduate student Qiuhan Jiang joins the lab. Welcome!
In the News
Prolonging our 'healthspan'
Dr. Bai attended CSHL aging conference and presented a poster on our cardiac aging research.
Mark Bouska joins the lab as a rotation student. Welcome!
Kerui Huang and Axelle Weeger officially join the lab as graduate students. Welcome!
Bai Lab went to 2016 The Allied Genetics Conference in Orlando, Florida. Kai, Allison and Ping presented posters at the conference.
We received 2016 AFAR Research Grant for Junior Faculty. Congratulations!
Dr. Ying Liu, our new postdoc researcher, joins the lab. Welcome!
Fahmo Mohamed, our 2016 George Washington Carver summer research intern, joins the lab. Welcome!
Jazmine Real, our 2016 HHMI summer research intern, joins the lab. Welcome!
Our undergraduate Sheridan Schwartz won Sui Tong Chan Fung Internship in Genetics. Congratulations!
Allison Birnbaum joins the lab as a rotation student. Welcome!
We have our first demography (lifespan analysis) set up. Thank you Ping and all of the undergraduate students for your hard work!
Interview with Iowa State Daily.
Kai Chang joins the lab as a Laboratory Technician. she will join our IG2 graduate program in Fall 2016 with a F. Wendell Miller Fellowship. Congratulations!
Our NIH-NIA R00 award finally came $$ (Project entitled, “Activin-Mediated Autophagy During Cardiac Aging")
On GDCB departmental news.
Undergraduate students Audrey, Emily, Sheridan, Matt and Larsa join the lab. Welcome!
The Bai Lab is officially established! We are located at 3238 Molecular Biology Building ( 'We' means myself and Assistant Scientist Ping).
Trainee Fellowships & Grants
2020 Kalman/AFAR Scholarships for Research in the Biology of Aging
American Heart Association (AHA) Predoctoral Fellowship
Glenn/AFAR Scholarship for Research on the Biology of Aging
ISU Research Excellence Award (REX)
American Heart Association (AHA) Predoctoral Fellowship
ISU F. Wendell Miller Scholarship
2016 ISU Presidential Fellowship
2021 ISU Teaching Excellence Award
2019 ISU David Gladson Scholarship
2016 ISU Presidential Fellowship
Dean's High Impact Award for Undergraduate Research, Fall 2020
Sui Tong Chan Fung Internship in Genetics, Summer 2020
Dean's High Impact Award for Undergraduate Research, Fall 2019
Sui Tong Chan Fung Internship in Genetics, Summer 2018
Sui Tong Chan Fung Internship in Genetics, Summer 2016